Universal CARs, universal T cells, and universal CAR T cells

Mani and shapur a universal faith for e universal kingdom

mSA2 affinity-enhanced biotin-binding CAR T cells for universal tumor targeting

Chimeric antigen receptor T cells (CAR-Ts) are promising cancer therapeutics. However, since cancer cells can lose the CAR-targeted antigen and avoid destruction, targeting multiple antigens with multiple CARs has been proposed. We illustrate here a less cumbersome alternative, anti-tag CARs (AT-CARs) that bind to tags on tumor-targeting antibodies. We have created novel AT-CARs, using the affi...

Design and development of CAR-T cells for cancer therapy

Introduction: Today, treatment with CAR-T cells is accepted as an effective treatment for blood malignancies. CAR-T cells are autologous T cells that are engineered by gene transfer techniques to express a chimeric antigen receptor (CAR). Despite the promising results and the approval of six CAR-T cell products; these products have not yet been approved for solid tumors. In addition, the high c...

FLOWS AND UNIVERSAL COMPACTIFICATIONS

The main purpose of this paper is to establish a relation between universality of certain P-compactifications of a semitopological semigroup and their corresponding enveloping semigroups. In particular, we show that if we take P to be the property that the enveloping semigroup of a compactification of a semitopological semigroup s is left simple, a group, or the trivial singleton semigroup, t...

Strict Archimedean t-norms and t-conorms as universal approximators

In knowledge representation, when we have to use logical connectives, various continuous t-norms and t-conorms are used. In this paper, we show that every continuous t-norm and t-conorm can be approximated, to an arbitrary degree of accuracy, by a strict Archimedean t-norm (t-conorm).